科研服务
  • 细胞技术服务
  • 科研服务
SERVICE BRIEF

Humanpbmc was transplanted into m-nsg immunodeficient mice to rapidly reconstruct the human immune system. It is suitable for the evaluation of various T cell related immunotherapies.

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MODEL ADVANTAGES
IMMUNE SYSTEM RECONSTRUCTION IS FAST AND THE MODEL PRICE IS LOW
TUMOR MODEL SUITABLE FOR RAPID TUMORIGENESIS
MODEL SHORTCOMINGS
GVHD began to appear 3-4 weeks after reconstruction
Not suitable for tumors with slow tumorigenesis
Only human T cell reconstitution
M-NSG IMMUNODEFICIENT MICE

The degree of immune deficiency is high, which is at the same level as Japan nog, and the health status is good. It is applicable to the reconstruction of cd34+hsc/pbmc humanized immune system.

WE PROVIDE YOU WITH
Frozen PBMC suitable for in vivo immune reconstitution is preferred
The stock of preferred PBMC donor is very large, and a single donor PBMC stock can rebuild up to 1000 mice
The selected PBMC + m-nsg mice packaging product is suitable for preparing PBMC humanized mouse model, and provides technical guidance for the preparation of PBMC immune reconstituted mice
Mature PBMC humanized model in vivo efficacy evaluation service to evaluate various immunotherapies: pd-1/pd-l1 monoclonal antibodies, and other immune checkpoints / bispecific antibodies / oncolytic viruses
Professional in vivo pharmacodynamic service
相关服务
CONSTRUCTION OF PBMC IMMUNIZED MICE ADCC VALIDATION MLR ANIMAL PRIMARY CELL